발기부전 치료제의 가장 대표적인 부작용은 두통, 안면홍조, 소화불량, 가슴 두근거림, 근육통 등이다. 흔히의 부작용은 일시적이고 심하지 않기 때문에 별다른 걱정은 하지 않아도 된다. 물론 위험한 심장질환이나 뇌혈관 질환이 있는 병자는 복용금지다. 흔히 약화사고로 인한 사망사고 등은 실제 약물에 의한 것보다는 중금속 오염 등이 검사되어 식약처 등에서 단속하고 있는 가짜 약에 의한 경우다.
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해외 기준 20대 여성이 성기능 저하를 겪는 비율은 15% 정도(국민건강보험공단, 2019년)다. 그런가 하면 테스트 대상자의 약 31%가 '상대방과의 성관계보다 음란물들을 시청하는 일이 더 즐겁다'고 답했다. 결론적으로 조사 대상자의 3분의 1만 실제 성관계에 만족한다는 얘기다. 실험팀은 음란물을$L$289 성관계로 인한 흥분이 줄어들어 발기부전을 겪고 전반적인 만족도가 떨어지는 것으로 분석했다.
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